JUN antibody

• Background:

  Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306) . Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306) .

• Synonyms:

  Transcription factor Jun|Activator protein 1 (AP1) |Proto-oncogene c-Jun|Transcription factor AP-1 subunit Jun|V-jun avian sarcoma virus 17 oncogene homolog|p39|JUN

• Gene ID:

  3725

• UniProt:

  P05412

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Jun oncogene

• Target:

  JUN

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC, IF

• Field of Research:

  Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Neuroscience

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:50-1:500

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  40 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC, IF