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AMBRA1 antibody

CAT: 0710-FNab00356Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00356Size:100 µg
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Background
WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. AMBRA1 (Activating molecule in BECN1-regulated autophagy protein 1), also known as WDR94 or KIAA1736, is a 1, 298 amino acid protein that contains three WD repeats. Localized to cytoplasmic vesicles, AMBRA1 functions to control protein turnover, cell proliferation and cell survival during neuronal development, thereby playing an important role in autophagy and the development of the nervous system. Multiple isoforms of AMBRA1 exist due to alternative spicing events.
Synonyms
Activating molecule in BECN1-regulated autophagy protein 1|DDB1- and CUL4-associated factor 3|AMBRA1|DCAF3|KIAA1736
Gene ID
55626
UniProt
Q9C0C7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Autophagy/beclin-1 regulator 1
Target
AMBRA1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB
Field of Research
Neuroscience, Cardiovascular, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
140 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB

UniProtKB · Q9C0C7

Activating molecule in BECN1-regulated autophagy protein 1

AMRA1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9C0C7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AMBRA1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A6XN33, D3DQP8, G3V193, Q86XD6, Q9H8Z0, Q9NXE7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

AutophagyCell cycleDifferentiationNeurogenesisTranscriptionTranscription regulationUbl conjugation pathway

Cellular component

Cell junctionCytoplasmCytoplasmic vesicleCytoskeletonEndoplasmic reticulumMitochondrionNucleus

Molecular function

Developmental protein

PTM

Isopeptide bondMethylationPhosphoproteinUbl conjugation

Domain

RepeatWD repeat

Disease

Tumor suppressor

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