SNCA antibody

• Background :

  Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.

• Synonyms :

  Alpha-synuclein|Non-A beta component of AD amyloid|Non-A4 component of amyloid precursor (NACP) |SNCA|NACP|PARK1

• Gene ID :

  6622

• UniProt :

  P37840

• Host :

  Rabbit

• Reactivity :

  Human, Rat

• Immunogen :

  Synuclein, alpha (non A4 component of amyloid precursor)

• Target :

  SNCA

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, IHC, WB, IF

• Field of Research :

  Neuroscience

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  15 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, IHC, WB, IF

• Immunogen Sequence :

  61-140aa