CRYAB antibody

CAT: 0710-FNab00325Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab00325Size:100 µg
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Background
Alpha B-crystallin, encoded by CRYAB gene, is multifunctional, serving as both a major structural protein in the lens and a small heat-shock protein in other tissues in mammals. Alpha B-crystallin may contribute to the transparency and refractive index of the lens. Single nucleotide polymorphisms (SNPs) in the promoter region of CRYAB gene have been associated with in multiple sclerosis. Mutations in the CRYAB gene cause distinct clinical phenotypes including isolated posterior polar cataract, myofibrillar myopathy, cardiomyopathy, or a multisystemic disorder combining all these features. Impairment of alpha-B crystallin dimerization may be relevant to the pathogenesis of these disorders.
Synonyms
Alpha-crystallin B chain|Alpha (B) -crystallin|Heat shock protein beta-5 (HspB5) |Renal carcinoma antigen NY-REN-27|Rosenthal fiber component|CRYAB|CRYA2|HSPB5
UniProt
P02511
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Crystallin, alpha B
Target
CRYAB
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Neuroscience, Cancer, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
20 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP

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