ALK antibody

• Background :

  Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDL Receptor (LDLR) class A domain, two meprin/A5-protein/PTPmu (MAM) domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein result in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellular transformation. ALK translocations are found in a variety of tumors. Within the extracellular domain, human and mouse ALK share 88% amino acid sequence identity.

• Synonyms :

  ALK tyrosine kinase receptor|Anaplastic lymphoma kinase|ALK

• Gene ID :

  238

• UniProt :

  Q9UM73

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Anaplastic lymphoma receptor tyrosine kinase

• Target :

  ALK

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, IHC, WB

• Field of Research :

  Signal Transduction, Metabolism, Immunology, Cancer, Developmental biology, Neuroscience

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:2000; IHC: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  140-220 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, IHC, WB

• Immunogen Sequence :

  1406-1545