ALDH2 antibody

CAT: 0710-FNab00291Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0710-FNab00291Size:100 µg

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Background

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Synonyms

Gene ID

217

UniProt

P05091

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Aldehyde dehydrogenase 2 family (mitochondrial)

Target

ALDH2

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB, IHC, IF

Field of Research

Metabolism

Purification

Immunogen affinity purified

Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

53 kDa

Shipping Conditions

4°C with ice bag

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, WB, IHC, IF

UniProtKB · P05091

Aldehyde dehydrogenase, mitochondrial

ALDH2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P05091
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: ALDH2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 1.2.1.19, 1.2.1.24, 1.2.1.3, 1.2.1.36, 1.2.1.46
Processing: Precursor
Secondary accessions: B4DW54, E7EUE5, Q03639, Q6IB13, Q6IV71

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationUbl conjugation

Coding sequence diversity

Alternative splicing

Disease

Disease variantDwarfismIntellectual disability

Cellular component

Mitochondrion

Ligand

NAD

Molecular function

Oxidoreductase

Domain

Transit peptide

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Alternative Products

Catalog	Name
10R-3287	ALDH2 antibody