ALCAM antibody

Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728) . Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728) . Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806) . Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806) . Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813) . Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771) . Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771) . Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity) . Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity) . Isoform 3: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation.

CD166 antigen|Activated leukocyte cell adhesion molecule|ALCAM|MEMD

214

Q13740

Human

Activated leukocyte cell adhesion molecule

ALCAM

ELISA, IHC, WB

Stem Cells, Immunology, Signal Transduction, Developmental biology

Immunogen affinity purified

WB: 1:200-1:2000; IHC: 1:20-1:200

≥95% as determined by SDS-PAGE

Liquid

110 kDa

4°C with ice bag

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)