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AKR7A2 antibody

CAT: 0710-FNab00266Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00266Size:100 µg
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Background
The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants.
Synonyms
Aflatoxin B1 aldehyde reductase member 2|AFB1 aldehyde reductase 1 (AFB1-AR 1) |Aldoketoreductase 7|Succinic semialdehyde reductase (SSA reductase) |AKR7A2|AFAR|AFAR1|AKR7
Gene ID
8574
UniProt
O43488
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
Target
AKR7A2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
40 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

UniProtKB · O43488

Aflatoxin B1 aldehyde reductase member 2

ARK72_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O43488
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AKR7A2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.1.1.n11
Processing
Precursor
Secondary accessions
O75749, Q5TG63
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Cellular component

CytoplasmGolgi apparatusMitochondrion

Biological process

Lipid metabolism

Ligand

NADP

Molecular function

Oxidoreductase

Domain

Transit peptide

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