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AIRE antibody

CAT: 0710-FNab00241Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00241Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity) . Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.
Synonyms
Autoimmune regulator|Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein (APECED protein) |AIRE|APECED
Gene ID
326
UniProt
O43918
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Autoimmune regulator
Target
AIRE
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IHC: 1:20-200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
60 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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