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AIM2 antibody

CAT: 0710-FNab00238Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00238Size:100 µg
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Background
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity) . Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Synonyms
Interferon-inducible protein AIM2|Absent in melanoma 2|AIM2
Gene ID
9447
UniProt
O14862
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Absent in melanoma 2
Target
AIM2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IHC: 1:20-200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
38-45 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
116-343aa

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