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AHR antibody

CAT: 0710-FNab00231Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00231Size:100 µg
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Background
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) . Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.
Synonyms
Aryl hydrocarbon receptor (Ah receptor, AhR) |Class E basic helix-loop-helix protein 76 (bHLHe76) |AHR|BHLHE76
Gene ID
196
UniProt
P35869
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Aryl hydrocarbon receptor
Target
AHR
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Epigenetics, Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
105 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP
Immunogen Sequence
12-215aa

UniProtKB · P35869

Aryl hydrocarbon receptor

AHR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35869
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AHR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Ah receptor, AhR
EC number
—
Processing
Precursor
Secondary accessions
A4D130, Q13728, Q13803, Q13804
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationADP-ribosylation

Molecular function

ActivatorDNA-bindingReceptorRepressor

Biological process

Biological rhythmsCell cycleTranscriptionTranscription regulation

Cellular component

CytoplasmNucleus

Disease

Disease variantRetinitis pigmentosa

Domain

Repeat

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