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GPSM1 antibody

CAT: 0710-FNab00221Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00221Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GPSM1, also named as AGS3, is a receptor-independent G protein activator that has been implicated in multiple biological events such as brain development, neuroplasticity and addiction, cardiac function, Golgi structure/function, macroautophagy and metabolism. It contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. It has been shown that AGS3 could regulate the orientation of the mitotic spindle, cAMP production, membrane protein transport, and asymmetric cell division by binding preferentially to inactive Gai/o subunits complexed with guanine dinucleotide phosphate (GDP) at multiple G-protein regulatory or GoLoco motif repeats. It also plays an important anti-apoptotic role through enhancing the phosphorylation of cyclic AMP response element-binding protein (p-CREB) .
Synonyms
G-protein-signaling modulator 1|Activator of G-protein signaling 3|GPSM1|AGS3
Gene ID
26086
UniProt
Q86YR5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
G-protein signaling modulator 1 (AGS3-like, C. elegans)
Target
GPSM1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, IF, WB
Field of Research
Cell Division and Proliferation, Signal Transduction, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IF: 1:10-1:100; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
72 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, IF, WB

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