ADAR antibody

• Background :

  ADAR1 is also named as ADAR1, DSRAD, G1P1, IFI4. It convert selected adenosine residues into inosine in substrate RNAs containing a relatively short dsRNA region (PMID:15556947) . The human ADAR1 gene specifies two size forms of RNA-specific adenosine deaminase, an interferon (IFN) inducible ?150 kDa protein and a constitutively expressed N-terminally truncated ?110 kDa protein, encoded by transcripts with alternative exon 1 structures that initiate from different promoters (PMID:11111054) . It has 5 isoforms produced by alternative promoter usage and alternative splicing. Defects in ADAR are a cause of dyschromatosis symmetrical hereditaria (DSH) .ADAR1 can form respective homodimers, and this association is essential for its enzymatic activities (PMID:17428802) .

• Synonyms :

  Double-stranded RNA-specific adenosine deaminase (DRADA) |136 kDa double-stranded RNA-binding protein (p136) |Interferon-inducible protein 4 (IFI-4) |K88DSRBP|ADAR|ADAR1|DSRAD|G1P1|IFI4

• Gene ID :

  103

• UniProt :

  P55265

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Adenosine deaminase, RNA-specific

• Target :

  ADAR

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, IHC, IF, WB, IP

• Field of Research :

  Neuroscience, Immunology, Metabolism, Epigenetics

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:2000; IHC: 1:50-1:200; IP: 1:200-1:1000; IF: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  110 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, IHC, IF, WB, IP

• Immunogen Sequence :

  Peptide