ACTN4 antibody

• Background:

  F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable) . Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161) . Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity) . May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778) .

• Synonyms:

  Alpha-actinin-4|Non-muscle alpha-actinin 4|ACTN4

• Gene ID:

  81

• UniProt:

  O43707

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Actinin, alpha 4

• Target:

  ACTN4

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC, IF, IP, FC

• Field of Research:

  Immunology, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:500-1:5000; IF: 1:10-1:100

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  105 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC, IF, IP, FC

• Immunogen Sequence:

  720-911aa