Acetylated tubulin (Lys40) antibody
CAT:
710-FNab00082
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Acetylated tubulin (Lys40) antibody
- Background: Tubulin, composed of heterodimers of alpha and beta tubulin, is the mainly component of microtubules which play important roles in cell motility, mitosis, and intracellular vesicle transport. Both alpha and beta tubulin undergo several posttranslational modifications such as polyglutamylation and acetylation/deacetylation. Tubulin acetylation occurs on lysine-40 at the N-terminal of alpha tubulin and is conserved across species. The histone deacetylase HDAC6 and SIRT2 has been identified as tubulin deacetylases. Reversible acetylation of alpha tubulin may be implicated in regulating microtubule stability, cell motility, and axon regeneration. The level of acetylated tubulin has been linked to epithelial malignancies and sensitivity to chemotherapy. In addition, acetylated tubulin has been widely used as a marker for primary cilia. This antibody is specific to the acetylated tubulin; it does not recognize non-acetylated tubulin.
- Synonyms: Tubulin alpha-1A chain|Alpha-tubulin 3|Tubulin B-alpha-1|Tubulin alpha-3 chain|Detyrosinated tubulin alpha-1A chain|TUBA1A|TUBA3
- CAS Number: 9007-83-4
- Gene ID: 7846
- UniProt: Q71U36
- Host: Mouse
- Reactivity: Human, Mouse, Rat, Dog
- Immunogen: tubulin, alpha 1a
- Target: Acetylated tubulin (Lys40)
- Clonality: Monoclonal
- Isotype: IgG1
- Clone: 6A10
- Applications: ELISA, WB, IHC, IF
- Field of Research: Neuroscience, Cell Division and Proliferation, Metabolism
- Purification: Protein A+G purification
- Dilution: WB: 1:500-1:5000; IF: 1:20-1:200; IHC: 1:20-1:200
- Purity: ≥95% as determined by SDS-PAGE
- Form: Liquid
- Molecular Weight: 52 kDa
- Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)