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ACADVL antibody

CAT: 0710-FNab00068Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00068Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Very long-chain acyl-CoA dehydrogenase (VLCAD) is one of four flavoproteins which catalyze the initial step of the mitochondrial b-oxidation spiral. It belongs to the acyl-CoA dehydrogenase family and is a homodimer of a 71-kDa polypeptide. The molecular mass of the nondenatured trypsinized VLCAD is 98 kDa, by gel filtration chromatography, indicating that it is a homodimer of the 48 kDa (tryptic digest) polypeptide (PMID:9461620) . Defects in ACADVL are the cause of acyl-CoA dehydrogenase very long chain deficiency (ACADVLD) . It has 2 isoforms (70 kDa and 68 kDa) produced by alternative splicing and a transit peptide.
Synonyms
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) |ACADVL|VLCAD
Gene ID
37
UniProt
P49748
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Acyl-Coenzyme A dehydrogenase, very long chain
Target
ACADVL
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
48 kDa, 68-73 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
534-578aa

UniProtKB · P49748

Very long-chain acyl-CoA dehydrogenase, mitochondrial

ACADV_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P49748
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ACADVL
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
VLCAD
EC number
1.3.8.9
Processing
Precursor
Secondary accessions
B4DEB6, F5H2A9, O76056, Q8WUL0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinS-nitrosylation

Coding sequence diversity

Alternative splicing

Disease

CardiomyopathyDisease variant

Ligand

FADFlavoprotein

Biological process

Fatty acid metabolismLipid metabolism

Cellular component

MembraneMitochondrionMitochondrion inner membrane

Molecular function

Oxidoreductase

Domain

Transit peptide

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