ABHD2 antibody

• Background:

  Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199) . Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199) . Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199) . May also play a role in smooth muscle cells migration (By similarity) .

• Synonyms:

  Monoacylglycerol lipase ABHD2|2-arachidonoylglycerol hydrolase|Abhydrolase domain-containing protein 2|Acetylesterase|Lung alpha/beta hydrolase 2|Progesterone-sensitive lipase|Protein PHPS1-2|ABHD2|LABH2

• Gene ID:

  11057

• UniProt:

  P08910

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Abhydrolase domain containing 2

• Target:

  ABHD2

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:5000; IHC: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  48 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC