ABAT antibody

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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ABAT antibody

CAT:

710-FNab00026

Size:

100 µg

Price:

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For price, please contact [email protected].

Background: 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
Synonyms: 4-aminobutyrate aminotransferase, mitochondrial|(S)-3-amino-2-methylpropionate transaminase|GABA aminotransferase (GABA-AT)|Gamma-amino-N-butyrate transaminase (GABA transaminase, GABA-T)|L-AIBAT|ABAT|GABAT
Gene ID: 18
UniProt: P80404
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: 4-aminobutyrate aminotransferase
Target: ABAT
Clonality: Polyclonal
Isotype: IgG
Applications: ELISA, WB, IHC, IF
Field of Research: Neuroscience, Metabolism
Purification: Immunogen affinity purified
Dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular Weight: 49 kDa
Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

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