ABAT antibody

CAT: 0710-FNab00026Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab00026Size:100 µg
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Background
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
Synonyms
4-aminobutyrate aminotransferase, mitochondrial| (S) -3-amino-2-methylpropionate transaminase|GABA aminotransferase (GABA-AT) |Gamma-amino-N-butyrate transaminase (GABA transaminase, GABA-T) |L-AIBAT|ABAT|GABAT
Gene ID
18
UniProt
P80404
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
4-aminobutyrate aminotransferase
Target
ABAT
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Neuroscience, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
49 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

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