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Aspulvinone O

CAT: 0804-HY-N6237Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6237Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aspulvinone O is a selective inhibitor of glutamate oxaloacetate aminotransferase GOT1. Aspulvinone O inhibits glutamine metabolism and reduces NADPH production, thereby inducing oxidative stress and apoptosis in pancreatic ductal adenocarcinoma (PDAC) cells. Aspulvinone O inhibits PDAC cell proliferation in vitro and tumor growth in xenograft models[1][2].
CAS Number
914071-54-8
UNSPSC
12352005
Target
Aminotransferases (Transaminases) ; Apoptosis
Type
Natural Products
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aspulvinone-o.html
Purity
96.0
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
OC1=C(C2=CC(C/C=C(C)/C)=C(O)C=C2O)C(O/C1=C/C3=CC(C/C=C(C)/C)=C(O)C=C3)=O
Molecular Formula
C27H28O6
Molecular Weight
448.51
References & Citations
[1]Sun W, et al. Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism. Cell Commun Signal. 2019;17 (1) :111.|[2]Yan S, et al. Discovery of GOT1 Inhibitors from a Marine-Derived Aspergillus terreus That Act against Pancreatic Ductal Adenocarcinoma. Mar Drugs. 2021 Oct 20;19 (11) :588.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
GOT/AST

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PLB07154-01Aspulvinone O
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GTR19228925-01Aspulvinone E

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