3α,21-Dihydroxy-5α-pregnan-20-one-d3

3α,21-Dihydroxy-5α-pregnan-20-one-d3

• Product Name Alternative: THDOC-d3
• CAS Number: 203805-98-5
• UNSPSC Description: 3α,21-Dihydroxy-5α-pregnan-20-one-d3 is the deuterium labeled 3α,21-Dihydroxy-5α-pregnan-20-one. 3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.
• Target Antigen: GABA Receptor; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling;Others
• Field of Research: Neurological Disease
• Solubility: 10 mM in DMSO
• Smiles: C[C@@]12[C@](CC[C@]2([2H])C(C([2H])([2H])O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@@](C[C@@H](CC4)O)([H])CC3)C
• Molecular Weight: 337.51
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported