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Mioflazine

CAT: 0804-HY-U00049Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-U00049Size:1 Each
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Description
Mioflazine is an orally active nucleoside transport inhibitor with sleep-improving activity. Mioflazine significantly improves cardiac survival after global cardiac ischemia. Mioflazine inhibits nucleoside uptake Mioflazine does not exhibit inotropic effects during induction and nursing[1][2][3].
CAS Number
79467-23-5
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mioflazine.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=C(Cl)C=CC=C1Cl)CN2CC(C(N)=O)N(CCCC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)CC2
Molecular Formula
C29H30Cl2F2N4O2
Molecular Weight
575.48
References & Citations
[1]Wauquier A, et al. Sleep improvement in dogs after oral administration of mioflazine, a nucleoside transport inhibitor. Psychopharmacology (Berl) . 1987;91 (4) :434-9.|[2]Pirovano IM, et al. Inhibition of nucleoside uptake in human erythrocytes by a new series of compounds related to lidoflazine and mioflazine. Eur J Pharmacol. 1990 Dec 15;189 (6) :419-22.|[3]J G Hugtenburg, et al. The influence of nifedipine and mioflazine on mitochondrial calcium overload in normoxic and ischaemic guinea-pig hearts. Eur J Pharmacol. 1990 Mar 13;178 (1) :71-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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T68685-01Mioflazine hydrochloride
T68603-01Mioflazine hydrochloride anhydrous

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