Products for Research Use Only
RegisterLogin

Dibenzothiophene

CAT: 0804-HY-B0973-01Size: 500 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B0973-01Size:500 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Dibenzothiophene is an orally active and a noncompetitive CYP1A inhibitor. Dibenzothiophene inhibits CYP1A-mediated EROD activity with a Km of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone. Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms[1][2].
CAS Number
132-65-0
Product Name Alternative
DBT; Diphenylene sulfide
UNSPSC
12352005
Hazard Statement
H302, H410
Target
Aryl Hydrocarbon Receptor; Cytochrome P450
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Dibenzothiophene.html
Purity
99.98
Solubility
DMSO : 75 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C12=CC=CC=C1C3=CC=CC=C3S2
Molecular Formula
C12H8S
Molecular Weight
184.26
Precautions
H302, H410
References & Citations
[1]Wassenberg DM, et al. Effects of the polycyclic aromatic hydrocarbon heterocycles, carbazole and dibenzothiophene, on in vivo and in vitro CYP1A activity and polycyclic aromatic hydrocarbon-derived embryonic deformities. Environ Toxicol Chem. 2005 Oct;24 (10) :2526-32. |[2]Leighton FA. Acute oral toxicity of dibenzothiophene for male CD-1 mice: LD50, lesions, and the effect of preinduction of mixed-function oxidases. Fundam Appl Toxicol. 1989 May;12 (4) :787-92.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP1

Alternative Products

CatalogName
B1727-5000Dibenzothiophene
sc-227777Dibenzothiophene sulfone
OR51865-01Dibenzothiophene sulphone
D07920-01Dibenzothiophene 95%
TRC-D417345-5GDibenzothiophene-2-ol
TRC-D423125-50MGDibenzothiophene 5-Oxide

Popular Products