Recombinant Mouse CXCL1 Protein(Trx Tag)

Recombinant Mouse CXCL1 Protein(Trx Tag)

• Background: The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized roles in angiogenesis and inflammation. CXCL1 is a novel immediate PTH/PTHrP-responsive gene. CXCL1 may act as a chemoattractant for osteoclast precursors. CXCL1 may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis. CXCL1 plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection. CXCL1 functions throμgh CXCR2 to transactivate the EGFR by proteolytic cleavage of HB-EGF, leading to activation of MAPK signalling and increased proliferation of epithelial ovarian cancer (EOC) cells. It might limit tumor growth by reinforcing senescence early in tumorigenesis. Thus, CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis.
• Abbreviation: CXCL1
• Synonyms: CXCL;SCYB;Secretory protein N;Neutrophil-Activating Protein;GROα/CXCL;C-X-C Motif Chemokine 1;GRO-A;GRO-Alpha(1-73);Growth-Regulated Alpha Protein;GROα/CXCL1;Melanoma Growth Stimulatory Activity;NAP3;Neutrophil-Activating Protein 3;Platelet-derived growth factor-inducible protein KC;Secretory protein N51;CINC1;CINC-1;CXCL1;FSP;GRO1;GROa;KC;MGSA;MGSA-a;MGSA-alpha;NAP-3;SCYB1;GRO alpha;Growth Regulated Oncogene Alpha;Gro
• CAS Number: 9000-83-3
• UniProt: P12850
• Accession Number: P12850
• Host: E.coli
• Origin Species: Mouse
• Tag: N-Trx
• Sequence: Ala25-Lys96
• Field of Research: Cancer;Cell Biology;Cell Biology;Immunology
• Endotoxin: < 10 EU/mg of the protein as determined by the LAL method
• Purity: > 95% as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Form: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Calculated Molecular Weight: 27.9 kDa
• Observed Molecular Weight: 28 kDa