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Isomannide

CAT: 0804-HY-W013827-01Size: 25 gDry Ice: NoHazardous: No
CAT#:0804-HY-W013827-01Size:25 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Isomannide (1,4:3,6-Dianhydromannitol) is a common intermediate compound and derivative of Isosorbide (HY-B1469) . Some derivatives of isomannide have potent inhibitory effects on KLK5 and KLK7. Isomannide can be used in the research of HCV infection and KLK5/KLK7-related diseases[1][2][3].
CAS Number
[641-74-7]
Product Name Alternative
1,4:3,6-Dianhydromannitol
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
Biochemical Assay Reagents; Drug Derivative; Drug Intermediate
Type
Biochemical Assay Reagents
Related Pathways
Others
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/isomannide.html
Purity
99.97
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O[C@H]1[C@]2([H])[C@@](OC1)([H])[C@@H](CO2)O
Molecular Formula
C6H10O4
Molecular Weight
146.14
Precautions
H302, H315, H319, H335
References & Citations
[1]Rose M, et al. Isosorbide as a renewable platform chemical for versatile applications--quo vadis? ChemSusChem. 2012 Jan 9;5 (1) :167-76.|[2]Barros TG, et al. Pseudo-peptides derived from isomannide: inhibitors of serine proteases. Amino Acids. 2010 Mar;38 (3) :701-9.|[3]Oliveira JP, et al. Isomannide-based peptidomimetics as inhibitors for human tissue kallikreins 5 and 7. ACS Med Chem Lett. 2013 Dec 6;5 (2) :128-32.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

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