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SZU-B6

CAT: 0804-HY-168574-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-168574-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SZU-B6 is a PROTAC degrader for SIRT6 with DC50 of 45 nM and 154 nM in cell SK-HEP-1 and Huh-7. SZU-B6 inhibits the proliferation of cell SK-HEP-1 with an IC50 of 1.51 μM, inhibits the colony formation of SK-HEP-1 and Huh-7, induces apoptosis and arrests the cell cycle at G2/M phase in SK-HEP-1. SZU-B6 exhibits antitumor efficacy in mouse model. (Pink: ligand for target protein ; Black: linker (HY-W012935) ; BLue: ligand for E3 ligase (HY-W453548)
CAS Number
3059333-98-8
UNSPSC
12352211
Target
Apoptosis; PROTACs; Sirtuin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/szu-b6.html
Purity
98.78
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=C([N+]([O-])=O)C=CC(N2CCN(CC3CCN(C4=CC5=C(C(N(C6C(NC(CC6)=O)=O)C5=O)=O)C=C4F)CC3)CC2)=C1
Molecular Formula
C29H32FN7O6
Molecular Weight
593.61
References & Citations
[1]Huang J, et al., Discovery of Novel PROTAC SIRT6 Degraders with Potent Efficacy against Hepatocellular Carcinoma. J Med Chem. 2024 Oct 10;67 (19) :17319-17349.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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