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Columbin (Standard)

CAT: 0804-HY-N0389RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N0389RSize:1 Each
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Description
Columbin (Standard) is the analytical standard of Columbin. This product is intended for research and analytical applications. Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 μM) over COX-1 (EC50=327 μM) [1][2].
CAS Number
546-97-4
UNSPSC
12352005
Target
COX; Parasite; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Immunology/Inflammation; Others
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/columbin-standard.html
Smiles
O=C1[C@](C=C2)(O)[C@@](CC3)(C)[C@@]([C@@](C[C@@H](C4=COC=C4)O5)(C)[C@]3([H])C5=O)([H])[C@]2([H])O1
Molecular Formula
C20H22O6
Molecular Weight
358.39
References & Citations
[1]Ibrahim Abdelwahab S, et al. In vitro and in vivo anti-inflammatory activities of columbin through the inhibition of cycloxygenase-2 and nitric oxide but not the suppression of NF-κB translocation. Eur J Pharmacol. 2012 Mar 5;678 (1-3) :61-70.|[2]A J Nok, et al. Columbin inhibits cholesterol uptake in bloodstream forms of Trypanosoma brucei-A possible trypanocidal mechanism.J Enzyme Inhib Med Chem. 2005 Aug;20 (4) :365-8.|[3]Yang G, et al. Development and validation of an UPLC-MS/MS method for the quantification of columbin in biological matrices: Applications to absorption, metabolism, and pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:13-8
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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