Linaclotide

• Description :

  Linaclotide is a potent and selective guanylate cyclase C agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation.

• UNSPSC :

  12352209

• Hazard Statement :

  H302

• Target :

  Guanylate Cyclase

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Linaclotide.html

• Purity :

  99.77

• Solubility :

  DMSO : 50 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic; adjust pH to 2 with HCl)

• Smiles :

  O=C([C@@H](NC([C@@](CSSC[C@@H]1N)([H])NC([C@@](CSSC[C@H](N2)C(N[C@H](C(O)=O)CC3=CC=C(O)C=C3)=O)([H])NC([C@@H](NC([C@@H](N4)CCC(O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)CC(N)=O)N6[C@@](C(N[C@H](C(N[C@](CSSC[C@](C4=O)([H])NC1=O)([H])C(NC(C(NCC2=O)=O)[C@H](O)C)=O)=O)C)=O)([H])CCC6

• Molecular Formula :

  C59H79N15O21S6

• Molecular Weight :

  1526.74

• Precautions :

  H302

• References & Citations :

  [1]Bryant AP, et al. Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract. Life Sci. 2010 May 8;86 (19-20) :760-5.|[2]Love BL, et al. Linaclotide: a novel agent for chronic constipation and irritable bowel syndrome. Am J Health Syst Pharm. 2014 Jul 1;71 (13) :1081-91.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [851199-59-2]