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2-Iodoestradiol

CAT: 0804-HY-118124Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-118124Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2-Iodoestradiol is a potent human sex hormone binding globulin (SHBG) ligand with a remarkably high affinity for SHBG. 2-Iodoestradiol exhibits competition for the same binding site as dihydrotestosterone in binding to human SHBG. The binding affinity constant of 2-Iodoestradiol at physiological pH and 37 degrees Celsius is 2.4 x 10 (9) M-1, exceeding that for SHBG. 2-Iodoestradiol has been shown to bind to serum albumin, but with lower affinity. The radioisotope 125I-derivative of 2-Iodoestradiol has been used to study the binding properties of human SHBG, demonstrating its potential application in biological research[1].
CAS Number
24381-12-2
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/2-iodoestradiol.html
Smiles
C[C@@]12[C@](CC[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(I)=C(O)C=C4CC3
Molecular Formula
C18H23IO2
Molecular Weight
398.28
References & Citations
[1]2-Iodoestradiol binds with high affinity to human sex hormone binding globulin (SHBG)
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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