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MMV008138

CAT: 0804-HY-123561-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123561-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MMV008138 is a species-selective IspD (enzyme 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase) -targeting antimalarial agent, with an IC50 of 44 nM for PfIspD (P. falciparum IspD) . MMV008138 inhibits the growth of P. falciparum Dd2 strain with an IC50 of 250 nM[1][2].
CAS Number
1679333-73-3
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
Neuroscience-Neuromodulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mmv008138.html
Concentration
10mM
Purity
98.49
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C([C@@H]1CC2=C([C@@H](C3=CC=C(Cl)C=C3Cl)N1)NC4=C2C=CC=C4)O
Molecular Formula
C18H14Cl2N2O2
Molecular Weight
361.22
References & Citations
[1]Ghavami M, et al. Biological Studies and Target Engagement of the 2- C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD) -Targeting Antimalarial Agent (1 R,3 S) -MMV008138 and Analogs. ACS Infect Dis. 2018 Apr 13;4 (4) :549-559.|[2]Yao ZK, et al. Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies. Bioorg Med Chem Lett. 2015 Apr 1;25 (7) :1515-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Plasmodium

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