Hygromycin B

• Description:

  Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.

• Product Name Alternative:

  Hygrovetine

• UNSPSC:

  12352005

• Hazard Statement:

  H300+H310+H330

• Target:

  Antibiotic; Bacterial; Fungal; Parasite

• Type:

  Natural Products

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/Hygromycin-B.html

• Purity:

  99.93

• Solubility:

  DMSO : 66.67 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 125 mg/mL (ultrasonic)

• Smiles:

  O[C@H]([C@H]1O)C2(O[C@@]([C@@H](N)CO)([H])[C@@H]1O)O[C@@]([C@@H](O[C@@H]3CO)O[C@@]([C@H]([C@H](N)C4)O)([H])[C@@H]([C@H]4NC)O)([H])[C@@]([C@H]3O)([H])O2

• Molecular Formula:

  C20H37N3O13

• Molecular Weight:

  527.52

• Precautions:

  H300+H310+H330

• References & Citations:

  [1]Pardo JM, et al. Biochemical basis of resistance to hygromycin B in Streptomyces hygroscopicus--the producing organism. J Gen Microbiol. 1985 Jun;131 (6) :1289-98.|[2]González A, et al. Studies on the mode of action of hygromycin B, an inhibitor of translocation in eukaryotes. Biochim Biophys Acta. 1978 Dec 21;521 (2) :459-69.|[3]Pfister P, et al. Role of 16S rRNA Helix 44 in Ribosomal Resistance to Hygromycin B. Antimicrob Agents Chemother. 2003 May;47 (5) :1496-502.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Aminoglycoside

• CAS Number:

  [31282-04-9]