Lorediplon

CAT: 0804-HY-19371-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-19371-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Lorediplon is a novel non-benzodiazepine drug acting as a GABAA receptor modulator, differentially active at the alpha1-subunit, associated with promoting sleep. Target: GABA Lorediplon is a drug for the treatment of insomnia, has been successfully completed with a best-in-class efficacy profile in terms of maintaining sleep and sleep quality, Lorediplon targets GABAA. [1] Lorediplon demonstrates a minimum of 10-fold and 6-fold increase in potency (respectively) in the spontaneous motor activation studies. At concentrations of 1.2mg/kg, Lorediplon demonstrates a 57%increased effect on Slow Wave Sleep (SWS), when compared with a placebo.[2]

CAS Number

917393-39-6

UNSPSC

12352005

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Lorediplon.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(N(C1=CC(C2=CC=NC3=C(C(C4=CC=CS4)=O)C=NN23)=CC=C1F)C)=O

Molecular Formula

C20H15FN4O2S

Molecular Weight

394.42

References & Citations

[1]Zisapel N. Current Phase II investigational therapies for insomnia. Expert Opin Investig Drugs. 2015 Mar;24 (3) :401-411.|[2]Horoszok L, et al. A single-dose, randomized, double-blind, double dummy, placebo and positive-controlled, five-way cross-over study to assess the pharmacodynamic effects of lorediplon in a phase advance model of insomnia in healthy Caucasian adult male subjects. Hum Psychopharmacol. 2014 May;29 (3) :266-273.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Alternative Products

Catalog	Name
BA6676-50	Lorediplon
A13449-25	Lorediplon 25mg
A13449-100	Lorediplon 100mg
A13449-5	Lorediplon 5mg
A13449-50	Lorediplon 50mg
A13449-10	Lorediplon 10mg
A13449-10mM-D	Lorediplon 10mM * 1mL in DMSO

Lorediplon

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