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HIOC

CAT: 0804-HY-101446-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101446-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HIOC is a potent and selective activator of TrkB (tropomyosin related kinase B) receptor. HIOC can pass the blood-brain and blood-retinal barriers.HIOC activates TrkB/ERK pathway and decreases neuronal cell apoptosis. HIOC attenuates early brain injury after SAH (subarachnoid hemorrhage) . HIOC shows protective activity in an animal model for light-induced retinal degeneration[1][2][3].
CAS Number
314054-36-9
UNSPSC
12352005
Target
Apoptosis; ERK; Trk Receptor
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway; Neuronal Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hioc.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1C(NCCC1)=O)NCCC2=CNC3=C2C=C(O)C=C3
Molecular Formula
C16H19N3O3
Molecular Weight
301.34
References & Citations
[1]Tang J, et al. Neuroprotective role of an N-acetyl serotonin derivative via activation of tropomyosin-related kinase receptor B after subarachnoid hemorrhage in a rat model. Neurobiol Dis. 2015 Jun;78:126-33. |[2]Noah A.Setterholm, et al.Gram-scale, chemoselective synthesis of N-[2- (5-hydroxy-1H-indol-3-yl) ethyl]-2-oxopiperidine-3-carboxamide (HIOC) . Tetrahedron Letters. 3 June 2015;56 (23) :3413-3415.|[3]Ying Li, et al. Effect of systemic treatment with N-[2- (5-hydroxy-1H-indol-3-yl) ethyl]-2-oxopiperidine-3- carboxamide (HIOC) or tauroursodeoxycholic Acid (TUDCA) on retinal ganglion cell death following optic nerve crush. bioRxiv. 2019 August 14.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK; TrkB

Alternative Products

CatalogName
T37081-01HIOC
A24185-10HIOC 10mg
A24185-100HIOC 100mg
A24185-50HIOC 50mg
A24185-5HIOC 5mg
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5961/50HIOC 50 mg

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