Myelin basic protein (4-14)

CAT: 0804-HY-P1821-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P1821-01Size:5 mg
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Description
Myelin basic protein 4-14 (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (Km=7 μM) . Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca2+/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts[1][2].
CAS Number
[126768-94-3]
Product Name Alternative
MHP4-14
UNSPSC
12352209
Target
PKC
Type
Peptides
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/myelin-basic-protein-mbp.html
Purity
98.98
Solubility
H2O : ≥ 50 mg/mL
Smiles
O=C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(N)=O)N
Molecular Formula
C60H103N21O17
Molecular Weight
1390.59
References & Citations
[1]Farrar YJ, et al. A phosphatase resistant substrate for the assay of protein kinase C in crude tissue extracts. Biochem Biophys Res Commun. 1991;180 (2) :694-701. |[2]Yasuda I, et al. A synthetic peptide substrate for selective assay of protein kinase C. Biochem Biophys Res Commun. 1990;166 (3) :1220-1227.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Citation 01
Autophagy. 2020 Oct;16 (10) :1823-1837.|Heliyon. 2024 Oct 30;10 (21) :e39933.

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