Boc-Asp(OMe)-fluoromethyl ketone

• UNSPSC Description:

  Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8[1][2].

• Target Antigen:

  Caspase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/boc-asp-ome-fluoromethyl-ketone.html

• Purity:

  98.0

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(OC)C[C@H](NC(OC(C)(C)C)=O)C(CF)=O

• Molecular Weight:

  263.26

• References & Citations:

  [1]Paunel-Görgülü A, et al. Stimulation of Fas signaling down-regulates activity of neutrophils from major trauma patients with SIRS. Immunobiology. 2011;216(3):334-342.|[2]Koike A, et al. Pan-caspase inhibitors induce necroptosis via ROS-mediated activation of mixed lineage kinase domain-like protein and p38 in classically activated macrophages. Exp Cell Res. 2019;380(2):171-179.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  187389-53-3