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MRS1334

CAT: 0804-HY-103174-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103174-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MRS1334 is a potent and selective human adenosine A3 receptor antagonist with Kis of 2.69 nM, >100 nM, >100 nM for hA3, rA1, rA2A, respectively. MRS1334 blocks the protective effect of Cl-IB-MECA leading to significant bradycardia and elevated ST segment[1][2]. MRS1334 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
192053-05-7
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mrs1334.html
Purity
98.93
Solubility
DMSO : 52 mg/mL (ultrasonic; warming)
Smiles
O=C(C1=C(C)NC(C2=CC=CC=C2)=C(C(OCC3=CC=C([N+]([O-])=O)C=C3)=O)C1C#CC4=CC=CC=C4)OCC
Molecular Formula
C31H26N2O6
Molecular Weight
522.55
References & Citations
[1]P G Baraldi, et al. New potent and selective human adenosine A (3) receptor antagonists. Trends Pharmacol Sci. 2000 Dec;21 (12) :456-9.|[2]Aya Galal, et al. Selective A3 adenosine receptor agonist protects against doxorubicin-induced cardiotoxicity. Cancer Chemother Pharmacol. 2016 Feb;77 (2) :309-22.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A1 receptor (A1R) ; Adenosine A2A receptor (A2AR) ; Adenosine A3 receptor (A3R)

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