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Pegloxenatide

CAT: 0804-HY-P3491-01Size: 250 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-P3491-01Size:250 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pegloxenatide (Polyethylene glycol loxenatide) is a long-acting glucagon-like peptide-1 receptor (GLP-1RA) agonist. Pegloxenatide has various activities such as lowering blood glucose, lowering blood lipids, improving body weight, anti-inflammation, promoting wound healing, protecting the liver, and protecting the heart. Pegloxenatide can be used in the research of type 2 diabetes and its multiple complications[1][2][3][4].
CAS Number
2420483-82-3
Product Name Alternative
Polyethylene glycol loxenatide; PEX 168
UNSPSC
12352209
Target
Akt; AMPK; Apoptosis; Autophagy; GCGR; Interleukin Related; PI3K; Reactive Oxygen Species (ROS) ; Sirtuin
Type
Peptides
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pegloxenatide.html
Purity
90.00
Solubility
10 mM in DMSO
Smiles
[PEGn-H-{D-Ala}-EGTFTSDLSKQ-{Nle}-EEEAVRLFIEWLKQGGPSSGAPPPC-NH2]
Molecular Formula
(C2H4O) n (C2H4O) nC206H317N55O67S
References & Citations
[1]Wang J, et al. Polyethylene glycol loxenatide (PEX168) in subjects with renal impairment: A pharmacokinetic study. Br J Clin Pharmacol. 2019 Dec;85 (12) :2714-2720.|[2]Li XY, et al. Effect of polyethylene Glycol Loxenatide (long-acting GLP-1RA) on lipid, glucose levels and weight in type 2 diabetes mellitus patients with obesity. Eur Rev Med Pharmacol Sci. 2022 Nov;26 (21) :7996-8003.|[3]Zhang Y, et al. Protective Effects and Mechanisms of Polyethylene Glycol Loxenatide Against Hyperglycemia and Liver Injury in db/db diabetic Mice. Front Pharmacol. 2021 Dec 6;12:781856.|[4]Ding Z, et al. Polyethylene Glycol Loxenatide Accelerates Diabetic Wound Healing by Downregulating Systemic Inflammation and Improving Endothelial Progenitor Cell Functions. Int J Mol Sci. 2025 Mar 6;26 (5) :2367.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Peptides
Clinical Information
Phase 3

Alternative Products

CatalogName
GTR19035033-01Pegloxenatide

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