PCAF-IN-2

• Description:

  PCAF-IN-2 (compound 17) is a potent PCAF inhibitor with an IC50 value of 5.31 μM. PCAF-IN-2 shows anti-tumour activity. CAF-IN-2 induces apoptosis and arrest the cell cycle at the G2/M phase[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Histone Acetyltransferase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pcaf-in-2.html

• Purity:

  98.0

• Solubility:

  DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles:

  FC(C1=NN=C2N1N=C(NN)C3=C2C=CC=C3)(F)F

• Molecular Formula:

  C10H7F3N6

• Molecular Weight:

  268.20

• References & Citations:

  [1]Turky A, et al. Design, synthesis, and antitumor activity of novel compounds based on 1,2,4-triazolophthalazine scaffold: Apoptosis-inductive and PCAF-inhibitory effects. Bioorg Chem. 2020 Aug;101:104019.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  GCN5/PCAF

• CAS Number:

  56173-05-8