DEAE-dextran, MW 500000 (hydrochloride)

DEAE-dextran, MW 500000 (hydrochloride)

• CAS Number: 9064-91-9
• UNSPSC Description: DEAE-dextran, MW 500000 hydrochloride (DEAE-dextran, MW 500000 hydrochloride, from bacterial (Leuconostoc mesenteroides)) is a high-molecular-weight positively charged polymer that significantly enhances the uptake of viral RNA by tissue culture cells. When employed in the delivery system for "tumor immunity" RNA-splenocyte transfer, DEAE-dextran can markedly extend the lifespan of tumor-bearing animals, comparable to that of actively immunized animals. Furthermore, DEAE-dextran serves as a complexing agent for nucleic acids, forming composite particles with DNA/RNA for extensive applications in gene delivery. Additionally, DEAE-dextran can be utilized as a coating for liposomes[1][2].
• Target Antigen: Biochemical Assay Reagents
• Type: Biochemical Assay Reagents
• Related Pathways: Others
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/deae-dextran-mw-500000-hydrochloride.html
• Smiles: [DEAE-dextran, MW 500000 (hydrochloride)]
• Molecular Weight: 500000 (Average)
• References & Citations: [1]Rigby P G. Prolongation of survival of tumour-bearing animals by transfer of “immune” RNA with DEAE dextran[J]. Nature, 1969, 221(5184): 968-969.|[2]Siewert C, et al. Investigation of charge ratio variation in mRNA–DEAE-dextran polyplex delivery systems[J]. Biomaterials, 2019, 192: 612-620.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported