Guanine

• Description :

  Guanine is one of the fundamental components of nucleic acids (DNA and RNA) . Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects[1][2][3][4].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  DNA/RNA Synthesis; Endogenous Metabolite

• Type :

  Natural Products

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Guanine.html

• Purity :

  98.0

• Solubility :

  DMSO : 0.15 mg/mL (ultrasonic; warming) |H2O : < 0.1 mg/mL

• Smiles :

  O=C1N=C(N)NC2=C1NC=N2

• Molecular Formula :

  C5H5N5O

• Molecular Weight :

  151.13

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Mojzeš P, et al. Guanine, a high-capacity and rapid-turnover nitrogen reserve in microalgal cells. Proc Natl Acad Sci U S A. 2020 Dec 22;117 (51) :32722-32730. |[2]Chauhan V, et al. In Silico Discovery and Validation of Amide Based Small Molecule Targeting the Enzymatic Site of Shiga Toxin. J Med Chem. 2016 Dec 8;59 (23) :10763-10773. |[3]Messina E, et al. Guanine nucleotide depletion triggers cell cycle arrest and apoptosis in human neuroblastoma cell lines. Int J Cancer. 2004 Mar 1;108 (6) :812-7.|[4]de Oliveira ED, et al. Mechanisms involved in the antinociception induced by spinal administration of inosine or guanine in mice. Eur J Pharmacol. 2016 Feb 5;772:71-82.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  Phase 3

• Isoform :

  Human Endogenous Metabolite; Microbial Metabolite

• CAS Number :

  [73-40-5]