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Guanine

CAT: 0804-HY-Y1055-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-Y1055-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Guanine is one of the fundamental components of nucleic acids (DNA and RNA) . Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects[1][2][3][4].
CAS Number
73-40-5
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
DNA/RNA Synthesis; Endogenous Metabolite
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Guanine.html
Purity
98.0
Solubility
DMSO : 0.15 mg/mL (ultrasonic; warming) |H2O : < 0.1 mg/mL
Smiles
O=C1N=C(N)NC2=C1NC=N2
Molecular Formula
C5H5N5O
Molecular Weight
151.13
Precautions
H315, H319, H335
References & Citations
[1]Mojzeš P, et al. Guanine, a high-capacity and rapid-turnover nitrogen reserve in microalgal cells. Proc Natl Acad Sci U S A. 2020 Dec 22;117 (51) :32722-32730. |[2]Chauhan V, et al. In Silico Discovery and Validation of Amide Based Small Molecule Targeting the Enzymatic Site of Shiga Toxin. J Med Chem. 2016 Dec 8;59 (23) :10763-10773. |[3]Messina E, et al. Guanine nucleotide depletion triggers cell cycle arrest and apoptosis in human neuroblastoma cell lines. Int J Cancer. 2004 Mar 1;108 (6) :812-7.|[4]de Oliveira ED, et al. Mechanisms involved in the antinociception induced by spinal administration of inosine or guanine in mice. Eur J Pharmacol. 2016 Feb 5;772:71-82.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Phase 3
Isoform
Human Endogenous Metabolite; Microbial Metabolite

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