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Fiduxosin

CAT: 0804-HY-U00399Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-U00399Size:1 Each
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Description
Fiduxosin is a potent α1-adrenoceptor antagonist, with Ki of 0.160 nM, 24.9 nM, and 0.920 nM for α1a-, α1b-, and α1d-adrenoceptors, respectively.
CAS Number
208993-54-8
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/Fiduxosin.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCCCN2C[C@]3([H])[C@](COC4=CC=CC(OC)=C34)([H])C2)C5=C(NC1=O)C6=NC(C7=CC=CC=C7)=CN=C6S5
Molecular Formula
C30H29N5O4S
Molecular Weight
555.65
References & Citations
[1]Hancock AA, et al. Preclinical pharmacology of fiduxosin, a novel alpha (1) -adrenoceptor antagonist with uroselective properties. J Pharmacol Exp Ther. 2002 Feb;300 (2) :478-86.|[2]Brune ME, et al. Effect of fiduxosin, an antagonist selective for alpha (1A) - and alpha (1D) -adrenoceptors, on intraurethral and arterial pressure responses in conscious dogs. J Pharmacol Exp Ther. 2002 Feb;300 (2) :487-94.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α adrenergic receptor

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T69927-01Fiduxosin hydrochloride

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