Products for Research Use Only
RegisterLogin

MCI826

CAT: 0804-HY-U00247-02Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-U00247-02Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MCI826 is a P-glycoprotein (P-gp) antagonist.
CAS Number
140646-80-6
UNSPSC
12352005
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MCI826.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C(CC)(CC)CC(NC1=CC=CC(/C=C/C2=NC(C(C)C)=CS2)=C1)=O
Molecular Formula
C22H28N2O3S
Molecular Weight
400.53
References & Citations
[1]Morad SA, et al. Tamoxifen magnifies therapeutic impact of ceramide in human colorectal cancer cells independent of p53. Biochem Pharmacol. 2013 Apr 15;85 (8) :1057-65.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Mci 826

leukotriene D4 and E4 antagonist; inhibits late asthmatic response; structure in first source

CAS Number140646-80-6
PubChem CID6439428
IUPAC Name2,2-diethyl-4-oxo-4-[3-[(E)-2-(4-propan-2-yl-1,3-thiazol-2-yl)ethenyl]anilino]butanoic acid
Molecular FormulaC22H28N2O3S
Molecular Weight400.5
XLogP4.7
Topological Polar Surface Area108
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Heavy Atom Count28
Formal Charge0
Complexity560
SMILES
CCC(CC)(CC(=O)NC1=CC=CC(=C1)/C=C/C2=NC(=CS2)C(C)C)C(=O)O
InChI
InChI=1S/C22H28N2O3S/c1-5-22(6-2,21(26)27)13-19(25)23-17-9-7-8-16(12-17)10-11-20-24-18(14-28-20)15(3)4/h7-12,14-15H,5-6,13H2,1-4H3,(H,23,25)(H,26,27)/b11-10+
InChIKey
PGLNVMJTDKEOBE-ZHACJKMWSA-N
Chemical Structure
2D Structure
2D structure of Mci 826
CAS: 140646-80-6
CID: 6439428
Formula: C22H28N2O3S
MW: 400.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight400.5
XLogP34.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Exact Mass400.18206393
Monoisotopic Mass400.18206393
Topological Polar Surface Area108 Ų
Heavy Atom Count28
Formal Charge0
Complexity560
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
QFA64680MCI826

Popular Products