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MEN11467

CAT: 0804-HY-U00207-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-U00207-01Size:1 mg
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Description
MEN11467 is a selective and orally- effective peptidomimetic tachykinin NK1 receptor antagonist.
CAS Number
214487-46-4
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/MEN11467.html
Solubility
10 mM in DMSO
Smiles
CC(C=C1)=CC=C1CC(N(C)[C@H](CC2=CC3=CC=CC=C3C=C2)C(N[C@H](CCCC4)[C@H]4NC(C5=CNC6=C5C=CC=C6)=O)=O)=O
Molecular Formula
C38H40N4O3
Molecular Weight
600.75
References & Citations
[1]Cirillo R, et al. Pharmacology of MEN 11467: a potent new selective and orally- effective peptidomimetic tachykinin NK (1) receptor antagonist. Neuropeptides. 2001 Jun-Aug;35 (3-4) :137-47.|[2]Khan S, et al. Effect of the long-acting tachykinin NK (1) receptor antagonist MEN 11467 on tracheal mucus secretion in allergic ferrets. Br J Pharmacol. 2001 Jan;132 (1) :189-96.|[3]Palma C, et al. Anti-tumour activity of tachykinin NK1 receptor antagonists on human glioma U373 MG xenograft. Br J Cancer. 2000 Jan;82 (2) :480-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NK1R

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CatalogName
T12000-01MEN11467

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