Ecopladib

• Description :

  Ecopladib is a sub-micromolar inhibitor of cytosolic phospholipase A2α (cPLA2α), with IC50s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blood assays, respectively.

• Product Name Alternative :

  PLA 725

• UNSPSC :

  12352005

• Target :

  Phospholipase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/Ecopladib.html

• Purity :

  99.30

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O)C1=CC=C(OCCC2=C(CCNS(=O)(CC3=CC=C(Cl)C(Cl)=C3)=O)N(C(C4=CC=CC=C4)C5=CC=CC=C5)C6=C2C=C(Cl)C=C6)C=C1

• Molecular Formula :

  C39H33Cl3N2O5S

• Molecular Weight :

  748.11

• References & Citations :

  [1]Lee KL, et al. Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha. J Med Chem. 2007 Mar 22;50 (6) :1380-400. Epub 2007 Feb 17.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [381683-92-7]