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Temarotene

CAT: 0804-HY-U00011-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-U00011-02Size:5 mg
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Description
Temarotene is an orally administered, particular arotinoid[1].
CAS Number
75078-91-0
Product Name Alternative
Ro 15-0778
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Temarotene.html
Solubility
10 mM in DMSO
Smiles
C/C(C1=CC2=C(C(C)(C)CCC2(C)C)C=C1)=C\C3=CC=CC=C3
Molecular Formula
C23H28
Molecular Weight
304.47
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Olsen DR, et al. Suppression of ornithine decarboxylase gene expression by retinoids in cultured human keratinocytes. J Invest Dermatol. 1990 Jan;94 (1) :33-6.|[2]Fenina N, et al. Concentration of Temarotene (Ro 15-0778) and its metabolite Ro 14-6113 in plasma and skin of hairless rat. Skin Pharmacol. 1993;6 (1) :61-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Temarotene

Temarotene is a small molecule drug. The usage of the INN stem '-arotene' in the name indicates that Temarotene is a arotinoid derivative. Temarotene has a monoisotopic molecular weight of 304.22 Da.

CAS Number75078-91-0
PubChem CID6436116
IUPAC Name1,1,4,4-tetramethyl-6-[(E)-1-phenylprop-1-en-2-yl]-2,3-dihydronaphthalene
Molecular FormulaC23H28
Molecular Weight304.5
XLogP7.9
Topological Polar Surface Area0
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count2
Heavy Atom Count23
Formal Charge0
Complexity433
SMILES
C/C(=C\C1=CC=CC=C1)/C2=CC3=C(C=C2)C(CCC3(C)C)(C)C
InChI
InChI=1S/C23H28/c1-17(15-18-9-7-6-8-10-18)19-11-12-20-21(16-19)23(4,5)14-13-22(20,2)3/h6-12,15-16H,13-14H2,1-5H3/b17-15+
InChIKey
MUJQTAMVZYFLCR-BMRADRMJSA-N
Chemical Structure
2D Structure
2D structure of Temarotene
CAS: 75078-91-0
CID: 6436116
Formula: C23H28
MW: 304.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight304.5
XLogP37.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count2
Exact Mass304.219100893
Monoisotopic Mass304.219100893
Topological Polar Surface Area0 Ų
Heavy Atom Count23
Formal Charge0
Complexity433
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19203017-01Temarotene

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