ALX 40-4C

• Description:

  ALX 40-4C is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM.

• UNSPSC:

  12352202

• Target:

  Apelin Receptor (APJ) ; CXCR

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Infection; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/ALX_40-4C.html

• Solubility:

  10 mM in H2O

• Smiles:

  N=C (N) NCCC[C@H] (C (N) =O) NC ([C@@H] (CCCNC (N) =N) NC ([C@@H] (CCCNC (N) =N) NC ([C@@H] (CCCNC (N) =N) NC ([C@@H] (CCCNC (N) =N) NC ([C@@H] (CCCNC (N) =N) NC ([C@@H] (CCCNC (N) =N) NC ([C@@H] (CCCNC (N) =N) NC ([C@H] (NC (C) =O) CCCNC (N) =N) =O) =O) =O) =O) =O) =O) =O) =O

• Molecular Formula:

  C56H113N37O10

• Molecular Weight:

  1464.74

• References & Citations:

  [1]Doranz BJ, et al. Safe use of the CXCR4 inhibitor ALX40-4C in humans. AIDS Res Hum Retroviruses. 2001 Apr 10;17 (6) :475-86.|[2]Armand-Ugón M, et al. HIV-1 resistance to the gp41-dependent fusion inhibitor C-34. Antiviral Res. 2003 Jul;59 (2) :137-42.|[3]Zhou N, et al. Binding of ALX40-4C to APJ, a CNS-based receptor, inhibits its utilization as a co-receptor by HIV-1. Virology. 2003 Jul 20;312 (1) :196-203.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  CXCR4

• CAS Number:

  143413-49-4