ALX 40-4C

• Description :

  ALX 40-4C is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM.

• UNSPSC :

  12352202

• Target :

  Apelin Receptor (APJ) ; CXCR

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Infection; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/ALX_40-4C.html

• Solubility :

  10 mM in H2O

• Smiles :

  N=C(N)NCCC[C@H](C(N)=O)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@H](NC(C)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O

• Molecular Formula :

  C56H113N37O10

• Molecular Weight :

  1464.74

• References & Citations :

  [1]Doranz BJ, et al. Safe use of the CXCR4 inhibitor ALX40-4C in humans. AIDS Res Hum Retroviruses. 2001 Apr 10;17 (6) :475-86.|[2]Armand-Ugón M, et al. HIV-1 resistance to the gp41-dependent fusion inhibitor C-34. Antiviral Res. 2003 Jul;59 (2) :137-42.|[3]Zhou N, et al. Binding of ALX40-4C to APJ, a CNS-based receptor, inhibits its utilization as a co-receptor by HIV-1. Virology. 2003 Jul 20;312 (1) :196-203.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• Isoform :

  CXCR4

• CAS Number :

  [143413-49-4]