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Etelcalcetide

CAT: 0804-HY-P1955Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P1955Size:1 Each
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Description
Etelcalcetide (AMG 416; KAI-4169) is a synthetic calcimimetic as an activator of the calcium sensing receptor (CaSR) . Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease[1][2].
CAS Number
1262780-97-1
Product Name Alternative
Velcalcetide; AMG 416; KAI-4169
UNSPSC
12352209
Hazard Statement
H302-H312-H332
Target
CaSR
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/etelcalcetide.html
Solubility
10 mM in DMSO
Smiles
N=C(N)NCCC[C@H](C(N)=O)NC([C@@H](C)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@@H](C)NC([C@H](NC(C)=O)CSSC[C@H](N)C(O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C38H73N21O10S2
Molecular Weight
1048.25
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1][1]Van Megen WH, et al. Differential parathyroid and kidney Ca2+-sensing receptor activation in autosomal dominant hypocalcemia 1[J]. EBioMedicine. 2022 Apr;78:103947. |[2]Fujioka A, et al. Effect of etelcalcetide on parathyroid hormone secretion by primary hyperparathyroidism patient-derived primary parathyroid cells[J]. J Bone Miner Metab. 2021 May;39 (3) :396-403.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Launched

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