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Reserpine-d9

CAT: 0804-HY-N0480S-01Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0480S-01Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Reserpine-d9 is the deuterium labeled Reserpine. Reserpine is an inhibitor of the vesicular monoamine transporter 2 (VMAT2) .
CAS Number
84759-11-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Isotope-Labeled Compounds; Monoamine Transporter
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Membrane Transporter/Ion Channel; Others
Field of Research
Neurological Disease; Cancer
Purity
97.0
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
COC([C@H]1[C@@]2([H])C[C@]3([H])C4=C(CCN3C[C@@]2([H])C[C@H]([C@@H]1OC)OC(C5=CC(OC([2H])([2H])[2H])=C(C(OC([2H])([2H])[2H])=C5)OC([2H])([2H])[2H])=O)C6=CC=C(OC)C=C6N4)=O
Molecular Formula
C33H31D9N2O9
Molecular Weight
617.73
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Antkiewicz-Michaluk L, et al. Withdrawal from repeated administration of a low dose of reserpine induced opposing adaptive changes in the noradrenaline and serotonin system function: a behavioral and neurochemical ex vivo and in vivo studies in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Mar 3;57:146-54.|[3]Hong B, et al. Reserpine Inhibit the JB6 P+ Cell Transformation Through Epigenetic Reactivation of Nrf2-Mediated Anti-oxidative Stress Pathway. AAPS J. 2016 May;18 (3) :659-69.|[4]Sreemantula S, et al. Reserpine methonitrate, a novel quaternary analogue of reserpine augments urinary excretion of VMA and 5-HIAA without affecting HVA in rats. BMC Pharmacol. 2004 Nov 16;4:30.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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