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Isocryptotanshinone

CAT: 0804-HY-N6651Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N6651Size:1 Each
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Description
Isocryptotanshinone is a dual STAT3 and PTP1B (IC50 = 56.1 μM) inhibitor. Isocryptotanshinone inhibits STAT3 by binding to the STAT3 SH2 domain to block phosphorylation and nuclear translocation[1][2]. Isocryptotanshinone exerts its anti-proliferative effect via the induction of cell cycle arrest, apoptosis, and pro-death autophagy, through the regulation of STAT3, AKT/mTOR and MAPK signaling pathways. Isocryptotanshinone suppresses the xenograft gastric cancer (GC) tumor growth in BALB/c nude mice. Isocryptotanshinone can be used for cancer research, such as lung cancer, breast cancer and GC[1][3][4].
CAS Number
22550-15-8
UNSPSC
12352005
Target
Akt; Apoptosis; Atg8/LC3; Autophagy; Bcl-2 Family; Caspase; CDK; EGFR; JAK; mTOR; p38 MAPK; PARP; Phosphatase; STAT; Survivin
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(C3=C(C=C2)C(C)(C)CCC3)C(C4=C1[C@H](C)CO4)=O
Molecular Formula
C19H20O3
Molecular Weight
296.36
References & Citations
[1]Guo S, et al. Isocryptotanshinone, a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells. J Drug Target. 2016 Dec;24 (10) :934-942.|[2]Han YM, et al. PTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza. Biol Pharm Bull. 2005 Sep;28 (9) :1795-7.|[3]Zhang X, et al. Isocryptotanshinone Induced Apoptosis and Activated MAPK Signaling in Human Breast Cancer MCF-7 Cells. J Breast Cancer. 2015 Jun;18 (2) :112-8.|[4]Chen ZM, et al. Inhibitory effects of isocryptotanshinone on gastric cancer. Sci Rep. 2018 Jun 18;8 (1) :9307.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
STAT3

Alternative Products

CatalogName
XAA55015-01Isocryptotanshinone

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