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Sotetsuflavone

CAT: 0804-HY-N2199Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2199Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sotetsuflavone is a flavonoid that can be isolated from Cycas revolute. Sotetsuflavone inhibits migration and invasion of A549 cells by reversing EMT, and induces cell apoptosis and autophagy. Sotetsuflavone inhibits HIF-1α, VEGF, angiostatin, MMP-9, and MMP-13 expression in A549 cells. Sotetsuflavone also protects mice against Crohn's disease (CD) -like colitis. Sotetsuflavone can be used for research of NSCLC[1][2].
CAS Number
2608-21-1
UNSPSC
12352005
Target
Apoptosis; Autophagy
Type
Natural Products
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Sotetsuflavone.html
Purity
96.75
Solubility
10 mM in DMSO
Smiles
O=C1C=C(C2=CC=C(O)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(O)C=C6O5)=O)=CC=C4O)C(OC)=CC(O)=C13
Molecular Formula
C31H20O10
Molecular Weight
552.48
References & Citations
[1]Coulerie P et al. Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp. Planta Med. 2013 Sep;79 (14) :1313-8.|[2]Li SH et al. Chemical constituents from Amentotaxus yunnanensis and Torreyayunnanensis. J Nat Prod. 2003 Jul;66 (7) :1002-5.|[3]Wang S, et al. Sotetsuflavone suppresses invasion and metastasis in non-small-cell lung cancer A549 cells by reversing EMT via the TNF-α/NF-κB and PI3K/AKT signaling pathway. Cell Death Discov. 2018 Feb 14;4:26.|[4]Ge S, et al. Sotetsuflavone ameliorates Crohn's disease-like colitis by inhibiting M1 macrophage-induced intestinal barrier damage via JNK and MAPK signalling. Eur J Pharmacol. 2023 Feb 5;940:175464.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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