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Warangalone

CAT: 0804-HY-N1074Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1074Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC50s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC50 of 3.5 μM.
CAS Number
4449-55-2
Product Name Alternative
Scandenolone
UNSPSC
12352005
Target
Parasite; PKA
Type
Natural Products
Related Pathways
Anti-infection; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Warangalone.html
Purity
97.08
Solubility
10 mM in DMSO
Smiles
O=C1C(C(O)=C(C=CC(C)(C)O2)C2=C3C/C=C(C)\C)=C3OC=C1C4=CC=C(O)C=C4
Molecular Formula
C25H24O5
Molecular Weight
404.46
References & Citations
[1]Tati Herlina, et al. ANTI-MALARIAL COMPOUND FROM THE STEM BARK OF Erythrina variegate. Indo. J. Chem., 2009, 9 (2), 308-311.|[2]Wang BH, et al. Specific inhibition of cyclic AMP-dependent protein kinase by warangalone and robustic acid. Phytochemistry. 1997 Mar;44 (5) :787-96.|[3]Induction of apoptosis by isoflavonoids from the leaves of Millettia taiwaniana in human leukemia HL-60 cells. Planta Med. 2006 Apr;72 (5) :424-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Plasmodium

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